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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
29/06/2021 |
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Data da última atualização: |
10/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, D. S.; FACCHINATTO, W. M.; SANTOS, D. M. dos; BONI, F. I.; VALDES, T. A.; LEITÃO, A.; GREMIÃO, M. P. D.; COLNAGO, L. A.; CAMPANA-FILHO, S. P.; RIBEIRO, S. J. L. |
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Afiliação: |
LUIZ ALBERTO COLNAGO, CNPDIA. |
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Título: |
N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan: Synthesis, physicochemical and biological properties. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
International Journal of Biological Macromolecules, v. 178, 2021. |
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Páginas: |
558?568 |
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ISSN: |
0141-8130 |
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DOI: |
https://doi.org/10.1016/j.ijbiomac.2021.02.031 |
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Idioma: |
Inglês |
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Conteúdo: |
Two samples of N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan (DPCat) with different average degrees of quaternization named as DPCat35 (DQ = 35%) and DPCat80 (DQ = 80%), were successfully synthesized by reacting glycidyltrimethylammonium chloride (GTMAC) with O-palmitoyl chitosan (DPCh) derivative (DS = 12%). Such amphiphilic derivatives of chitosan were fully water-soluble at 1.0 < pH < 12.0 and showed significant electrostatic stability enhancement of a self-assembly micellar nanostructure (100–320 nm) due to its positively-charged out-layer. In vitro mucoadhesive and cytotoxicity essays toward healthy fibroblast cells (Balb/C 3T3 clone A31 cell), human prostate cancer (DU145) and liver cancer (HepG2/ C3A) cell lines revealed that the biological properties of DPCat derivatives were strongly dependent on DQ. Additionally, DPCat35 had better interactions with the biological tissue and with mucin glycoproteins at pH 7.4 as well as exhibited potential to be used on the development of drug delivery systems for prostate and liver cancer treatment. |
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Palavras-Chave: |
Cancer therapy; Cytocompatible; Mucoadhesive; Positively-charged amphiphilic chitosan. |
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Categoria do assunto: |
-- |
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Marc: |
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001 2132632
005 2022-06-10
008 2021 bl uuuu u00u1 u #d
022 $a0141-8130
024 7 $ahttps://doi.org/10.1016/j.ijbiomac.2021.02.031$2DOI
100 1 $aSILVA, D. S.
245 $aN-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan$bSynthesis, physicochemical and biological properties.$h[electronic resource]
260 $c2021
300 $a558?568
520 $aTwo samples of N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan (DPCat) with different average degrees of quaternization named as DPCat35 (DQ = 35%) and DPCat80 (DQ = 80%), were successfully synthesized by reacting glycidyltrimethylammonium chloride (GTMAC) with O-palmitoyl chitosan (DPCh) derivative (DS = 12%). Such amphiphilic derivatives of chitosan were fully water-soluble at 1.0 < pH < 12.0 and showed significant electrostatic stability enhancement of a self-assembly micellar nanostructure (100–320 nm) due to its positively-charged out-layer. In vitro mucoadhesive and cytotoxicity essays toward healthy fibroblast cells (Balb/C 3T3 clone A31 cell), human prostate cancer (DU145) and liver cancer (HepG2/ C3A) cell lines revealed that the biological properties of DPCat derivatives were strongly dependent on DQ. Additionally, DPCat35 had better interactions with the biological tissue and with mucin glycoproteins at pH 7.4 as well as exhibited potential to be used on the development of drug delivery systems for prostate and liver cancer treatment.
653 $aCancer therapy
653 $aCytocompatible
653 $aMucoadhesive
653 $aPositively-charged amphiphilic chitosan
700 1 $aFACCHINATTO, W. M.
700 1 $aSANTOS, D. M. dos
700 1 $aBONI, F. I.
700 1 $aVALDES, T. A.
700 1 $aLEITÃO, A.
700 1 $aGREMIÃO, M. P. D.
700 1 $aCOLNAGO, L. A.
700 1 $aCAMPANA-FILHO, S. P.
700 1 $aRIBEIRO, S. J. L.
773 $tInternational Journal of Biological Macromolecules$gv. 178, 2021.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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